Structure of PDB 4xl4 Chain B

Receptor sequence
>4xl4B (length=392) Species: 863638 (Clostridium acetobutylicum EA 2018) [Search protein sequence]
MKEVVIASAVRTAIGSYGKSLKDVPAVDLGATAIKEAVKKAGIKPEDVNE
VILGNVLQAGLGQNPARQASFKAGLPVEIPAMTINKVCGSGLRTVSLAAQ
IIKAGDADVIIAGGMENMSRAPYLANNARWGYRMGNAKFVDEMITDGLWD
AFNDYHMGITAENIAERWNISREEQDEFALASQKKAEEAIKSGQFKDEIV
PVVIKGRKGETVVDTDEHPRFGSTIEGLAKLKPAFKKDGTVTAGNASGLN
DCAAVLVIMSAEKAKELGVKPLAKIVSYGSAGVDPAIMGYGPFYATKAAI
EKAGWTVDELDLIESNEAFAAQSLAVAKDLKFDMNKVNVNGGAIALGHPI
GASGARILVTLVHAMQKRDAKKGLATLSIGGGQGTAILLEKC
3D structure
PDB4xl4 Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C88 H348 S378 G380
Catalytic site (residue number reindexed from 1) C88 H348 S378 G380
Enzyme Commision number 2.3.1.9: acetyl-CoA C-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B L148 H156 M157 R220 L231 S247 A318 F319 H348 L148 H156 M157 R220 L231 S247 A318 F319 H348
Gene Ontology
Molecular Function
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0043857 N-acetylornithine carbamoyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4xl4, PDBe:4xl4, PDBj:4xl4
PDBsum4xl4
PubMed26391388
UniProtA0A0R4I970

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