Structure of PDB 4xgk Chain B

Receptor sequence
>4xgkB (length=386) Species: 257309 (Corynebacterium diphtheriae NCTC 13129) [Search protein sequence]
SDFDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYSEAEPET
GIEIHKYGAHLFHTSNKRVWDYVNQFTAFTGYQHRVFAMHNGTAYQFPMG
LGLINQFFGRYYTPDEARELIKEQSAEIDSKDATNLEEKAISLIGRPLYE
AFIRDYTAKQWQTDPKELPAGNITRLPVRYNFDNRYFNDTYEGLPVDGYA
QWLSNMADHENIEVRLDTDWFEVREDLRAQNPEAPVVYTGPLDRYFDYSE
GHLGWRTLDFETEVLNTGDFQGTPVMNYNDAEFPYTRIHEFRHFHPERED
RHPKDKTVIMKEYSRFAEEGDEPYYPINTPSDREMLFKYRELADAETESG
KVYFGGRLGTYQYLDMHMAIASALSMFDNKLVDALK
3D structure
PDB4xgk Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.
ChainB
Resolution2.652 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R176 R180 R257 R288 E313 Y364 D366
Catalytic site (residue number reindexed from 1) R175 R179 R256 R287 E312 Y363 D365
Enzyme Commision number 5.4.99.9: UDP-galactopyranose mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 40K B Q161 W162 S315 Y326 Q160 W161 S314 Y325
BS02 FDA B V9 G10 G12 L13 F14 V33 E34 K35 R36 N42 Y58 A60 H61 L62 Y325 G357 R358 L365 D366 M367 V8 G9 G11 L12 F13 V32 E33 K34 R35 N41 Y57 A59 H60 L61 Y324 G356 R357 L364 D365 M366
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008767 UDP-galactopyranose mutase activity
GO:0016853 isomerase activity
GO:0050660 flavin adenine dinucleotide binding
Cellular Component
GO:0005829 cytosol

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4xgk, PDBe:4xgk, PDBj:4xgk
PDBsum4xgk
PubMed26214585
UniProtQ6NER4

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