Structure of PDB 4xey Chain B

Receptor sequence
>4xeyB (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV
YHYRINTASDGKLYVSRFNTLAELVHHHSTVADGLITTLHYPAPKYDKWE
MERTDITMKHKLEVYEGVWKKYSLTVAVKTLTMEVEEFLKEAAVMKEIKH
PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT
QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTA
HAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDL
SQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFET
MFQESSISD
3D structure
PDB4xey Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
ChainB
Resolution2.891 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D382 A384 R386 N387 D400 P421
Catalytic site (residue number reindexed from 1) D218 A220 R222 N223 D236 P257
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 B L267 A288 K290 M309 V318 I332 T334 M337 G340 L389 A399 F401 L112 A127 K129 M145 V154 I168 T170 M173 G176 L225 A235 F237 BindingDB: IC50=3.1nM,Kd=1.2nM,EC50=0.040000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xey, PDBe:4xey, PDBj:4xey
PDBsum4xey
PubMed25779001
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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