Structure of PDB 4xdo Chain B

Receptor sequence
>4xdoB (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
LNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQ
CYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYC
TPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVL
DVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKS
WYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPF
DKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCT
CRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTK
3D structure
PDB4xdo A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening.
ChainB
Resolution1.97 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G172 Y179 H190 E192 H278 S290
Catalytic site (residue number reindexed from 1) G163 Y170 H181 E183 H269 S281
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C236 H242 C308 C310 C227 H233 C299 C301
BS02 FE B H190 E192 H278 H181 E183 H269
External links
PDB RCSB:4xdo, PDBe:4xdo, PDBj:4xdo
PDBsum4xdo
PubMed25755264
UniProtQ9H3R0|KDM4C_HUMAN Lysine-specific demethylase 4C (Gene Name=KDM4C)

[Back to BioLiP]