Structure of PDB 4xdl Chain B

Receptor sequence
>4xdlB (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITT
IGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARV
EKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESI
YFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSM
IGDWLRV
3D structure
PDB4xdl K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K B I173 G174 Y175 V282 G283 F284 I101 G102 Y103 V210 G211 F212
BS02 K B T172 T281 T100 T209
BS03 40D B I197 P198 I125 P126
BS04 K B T172 I173 G174 T281 V282 G283 T100 I101 G102 T209 V210 G211
BS05 40D B T280 F316 T208 F244
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4xdl, PDBe:4xdl, PDBj:4xdl
PDBsum4xdl
PubMed25766236
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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