Structure of PDB 4xdk Chain B

Receptor sequence

>4xdkB (length=251) Species: 9606 (Homo sapiens)

KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITT
IGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARV
SQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTT
VGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLS
K

3D structure

• PDB: 4xdk K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
• Chain: B
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	K	B	I173 G174 Y175 V282 G283 F284	I101 G102 Y103 V201 G202 F203
BS02	K	B	T172 I173 G174 T281 V282 G283	T100 I101 G102 T200 V201 G202
BS03	K	B	T172 T281	T100 T200
BS04	408	B	I194 I197 P198	I122 I125 P126
BS05	405	B	I194 P198	I122 P126
BS06	405	B	V253 L279 T280 F316 L320	V172 L198 T199 F235 L239
BS07	408	B	L279 T280 F316	L198 T199 F235

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity

Biological Process

• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4xdk, PDBe:4xdk, PDBj:4xdk
• PDBsum: 4xdk
• PubMed: 25766236
• UniProt: P57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)