Structure of PDB 4xdj Chain B

Receptor sequence
>4xdjB (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGSHWDLGSAFFFAGTVITTIGYGNI
APSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFSQ
TKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVG
FGDFVAGGREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSK
3D structure
PDB4xdj K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
ChainB
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K B I173 G174 Y175 V282 G283 F284 I95 G96 Y97 V199 G200 F201
BS02 K B T172 I173 G174 T281 V282 T94 I95 G96 T198 V199
BS03 K B T172 T281 T94 T198
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xdj, PDBe:4xdj, PDBj:4xdj
PDBsum4xdj
PubMed25766236
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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