Structure of PDB 4xc6 Chain B

Receptor sequence
>4xc6B (length=1061) Species: 266264 (Cupriavidus metallidurans CH34) [Search protein sequence]
GPANKVRFVTAASLFDGHDASINIMRRILQSQGCEVIHLGHNRSVQEVVT
AALQEDVQGIAISSYQGGHVEYFKYMIDLLREHGGEHIQVFGGGGGVIVP
DEIRELQAYGVARIYSPEDGQRMGLAGMITDMAQRCDIDLTRYAPTTLDT
VVAGDRRALAQLITALENGKADPELVSALHAQAKAAAVPVLGITGTGGAG
KSSLTDELIRRFRLDQDDALSIAVISIDPSRRKSGGALLGDRIRMNAINH
PNIFMRSLATREAGSEISQALPDVIAACKAARFDLVIVETSGIGQGDAAI
VPHVDLSLYVMTPEFGAASQLEKIDMLDFADFVAINKFDRKGAQDAWRDV
AKQVQRNREQWHSRAEDMPVYGTQASRFNDDGVTMLYQGLVGALGARGMS
LKPGTLPNLEGRISTGQNVIVPPARSRYLAELADTVRAYHRRVVAQSKLA
RERQQLRAAHDMLQGAGHESAALETLASERDVSLGAVERKLLAMWPQMQQ
AYSGDEYVVKIRDKEIRTGLISTTLSGTKIRKVVLPRFEDEGEILKWLMR
ENVPGSFPYTAGVFAFKREGDPTRMFAGEGDAFRTNRRFKLVSEGMEAKR
LSTAFDSVTLYGEDPHERPDIYGKVGNSGVSIATLEDMKVLYDGFDLTNP
STSVSMTINGPAPTILAMFMNTAIDQQIDRFRADNGRDPTADEEAKIRAW
VLQNVRGTVQADILKEDQGQNTCIFSTEFSLKVMGDIQEYFVHHQVRNFY
SVSISGYHIAEAGANPISQLAFTLANGFTYVEAYLARGMHIDDFAPNLSF
FFSNGMDPEYSVLGRVARRIWAVTMRDKYGANDRSQKLKYHIQTSGRSLH
AQEIDFNDIRTTLQALIAIYDNCNSLHTNAYDITTPTAESVRRALAIQLI
INREWGVAKCENPNQGSFLIEELTDLVEEAVLQEFERIAERGGVLGAMET
GYQRGKIQEESLYYEQLKHDGTLPIIGVNTFRNPNGLARSSEDEKQSQLH
RLTEFHGAHQADAEAMLARLRQAVIDNRNVFAVLMDAVRVCSLGQITHAL
FEVGGQYRRNM
3D structure
PDB4xc6 Visualization of a radical B12 enzyme with its G-protein chaperone.
ChainB
Resolution3.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K26 F598 Y779 H780
Catalytic site (residue number reindexed from 1) K5 F576 Y757 H758
Enzyme Commision number 3.6.5.-
5.4.99.13: isobutyryl-CoA mutase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0003924 GTPase activity
GO:0004494 methylmalonyl-CoA mutase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016866 intramolecular transferase activity
GO:0031419 cobalamin binding
GO:0034784 pivalyl-CoA mutase activity
GO:0046872 metal ion binding
GO:0047727 isobutyryl-CoA mutase activity
Biological Process
GO:0006637 acyl-CoA metabolic process

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Molecular Function

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Biological Process
External links
PDB RCSB:4xc6, PDBe:4xc6, PDBj:4xc6
PDBsum4xc6
PubMed25675500
UniProtQ1LRY0|ICMF_CUPMC Fused isobutyryl-CoA mutase (Gene Name=icmF)

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