Structure of PDB 4x9e Chain B

Receptor sequence
>4x9eB (length=495) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AQIDFRKKINWHRRYRSPQGVKTEHEILRIFESDRGRIINSPAIRRLQQK
TQVFPNAAVRTRLTHSMEVQQVGRYIAKEILSRLKELKLLEAYGLDELTG
PFESIVEMSCLMHDIGNPPFGHFGEAAINDWFRQRLHPEDAQPLTDDRCS
VAALRLRDGEEPLNELRRKIRQDLCHFEGNAQGIRLVHTLMRMNLTWAQV
GGILKYTRPAWWRGETPETHHYLMKKPGYYLSEEAYIARLRKELNLALYS
RFPLTWIMEAADDISYCVADLEDAVEKRIFTVEQLYHHLHEAWGQHEKGS
LFSLVVENAWEKSRSRSTEDQFFMYLRVNTLNKLVPYAAQRFIDNLPAIF
AGTFNHALLEDASECSDLLKLYKNVAVKHVFSHPDVERLELQGYRVISGL
LEIYRPLLSLSLSDFTELVEKERVKRFPIESRLFHKLSTRHRLAYVEAVS
KLPSDSPEFPLWEYYYRCRLLQDYISGMTDLYAWDEYRRLMAVEQ
3D structure
PDB4x9e Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES.
ChainB
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 H117 D118 D268 R442
Catalytic site (residue number reindexed from 1) H65 H113 D114 D262 R432
Enzyme Commision number 3.1.5.1: dGTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Y79 M334 R337 V338 Y75 M324 R327 V328
BS02 rna B Y16 R17 R30 E33 S34 G37 R38 R198 Y15 R16 R29 E32 S33 G36 R37 R192
BS03 MG B H69 H117 D268 H65 H113 D262
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0003924 GTPase activity
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0050897 cobalt ion binding
Biological Process
GO:0006203 dGTP catabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0043099 pyrimidine deoxyribonucleoside salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:4x9e, PDBe:4x9e, PDBj:4x9e
PDBsum4x9e
PubMed25694425
UniProtP15723|DGTP_ECOLI Deoxyguanosinetriphosphate triphosphohydrolase (Gene Name=dgt)

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