Structure of PDB 4x8d Chain B

Receptor sequence
>4x8dB (length=426) Species: 1078020 (Mycolicibacterium thermoresistibile ATCC 19527) [Search protein sequence]
HRAELARQLIDARNRTLRLVDFDDAELRRQYDPLMSPLVWDLAHIGQQEE
LWLLRGGDPRRPGLLEPAVEQLYDAFVHPRASRVHLPLLSPAQARRFCAT
VRSAVLDALDRLPEDADTFAFGMVVSHEHQHDETMLQALNLRSGEPLLGS
GTALPPGRPGVAGTSVLVPGGPFVLGVDLADEPYALDNERPAHVVDVPAF
RIGRVPVTNAEWRAFIDDGGYRQRRWWSDAGWAYRCEAGLTAPQFWNPDG
TRTRFGHVEDIPPDEPVQHVTYFEAEAYAAWAGARLPTEIEWEKACAWDP
ATGRRRRYPWGDAAPTAALANLGGDALRPAPVGAYPAGASACGAEQMLGD
VWEWTSSPLRPWPGFTPMIYQRYSQPFFEGAGSGDYRVLRGGSWAVAADI
LRPSFRNWDHPIRRQIFAGVRLAWDV
3D structure
PDB4x8d Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway.
ChainB
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.99.50: gamma-glutamyl hercynylcysteine S-oxide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3GC B H51 R87 R90 H138 D416 R420 H44 R80 R83 H131 D409 R413
BS02 AVI B H134 Q137 H138 Y380 W415 H127 Q130 H131 Y373 W408
BS03 MN B H51 H134 H138 H44 H127 H131
BS04 CA B M354 G356 V358 E360 G398 G399 M347 G349 V351 E353 G391 G392
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0044875 gamma-glutamyl hercynylcysteine sulfoxide synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

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Molecular Function
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Biological Process
External links
PDB RCSB:4x8d, PDBe:4x8d, PDBj:4x8d
PDBsum4x8d
PubMed25597398
UniProtG7CFI3|EGTB_MYCT3 Hercynine oxygenase (Gene Name=egtB)

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