Structure of PDB 4x81 Chain B

Receptor sequence
>4x81B (length=250) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
STGVELYLDLLKRTVSNFIYQDATHVAGLITQAAFVEEARESGEDYPTVA
HTAIGMKRLNNLQHCVESALRDGVPGDVLETGVWRGGACIFARGILKAYD
VRDRTVWVADSFQGFPKITDDDHPMDAEMNLHQYNAAVDLPTSLATVQRN
FSRYGLLDDQVRFLPGWFKDTMPTAPFERLAVLRMDGDSYGATMDVLTHA
YPRLSPGGFAIIDDYCIPACREAVHEYRDRHGISDEIVEIDRQGVYWRRS
3D structure
PDB4x81 Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases.
ChainB
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.237: mycinamicin III 3''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B T55 A56 I57 E83 G85 V86 W87 D113 S114 G117 F118 L143 W170 F171 D189 T52 A53 I54 E80 G82 V83 W84 D110 S111 G114 F115 L140 W167 F168 D186
BS02 MG B D189 D216 D217 D186 D213 D214
BS03 MVI B Y49 M132 L134 Y137 D191 D217 Q246 Y46 M129 L131 Y134 D188 D214 Q243
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0036094 small molecule binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4x81, PDBe:4x81, PDBj:4x81
PDBsum4x81
PubMed25692963
UniProtQ49492|MYCF_MICGR Mycinamicin III 3''-O-methyltransferase (Gene Name=mycF)

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