Structure of PDB 4x7z Chain B

Receptor sequence
>4x7zB (length=251) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
STGVELYLDLLKRTVSNFIYQDATHVAGLITQAAFVEEARESGEDYPTVA
HTAIGMKRLNNLQHCVESALRDGVPGDVLETGVWRGGACIFARGILKAYD
VRDRTVWVADSFQGFPKITDDDHPMDAEMNLHQYNAAVDLPTSLATVQRN
FSRYGLLDDQVRFLPGWFKDTMPTAPFERLAVLRMDGDSYGATMDVLTHA
YPRLSPGGFAIIDDYCIPACREAVHEYRDRHGISDEIVEIDRQGVYWRRS
A
3D structure
PDB4x7z Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases.
ChainB
Resolution1.44 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.237: mycinamicin III 3''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B T55 A56 I57 E83 G85 V86 W87 D113 S114 G117 F118 W170 F171 D189 T52 A53 I54 E80 G82 V83 W84 D110 S111 G114 F115 W167 F168 D186
BS02 MG B D189 D216 D217 D186 D213 D214
BS03 ZM3 B Y49 L134 Y137 D191 D217 Q246 Y46 L131 Y134 D188 D214 Q243
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0036094 small molecule binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4x7z, PDBe:4x7z, PDBj:4x7z
PDBsum4x7z
PubMed25692963
UniProtQ49492|MYCF_MICGR Mycinamicin III 3''-O-methyltransferase (Gene Name=mycF)

[Back to BioLiP]