Structure of PDB 4x7v Chain B

Receptor sequence
>4x7vB (length=252) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
PSTGVELYLDLLKRTVSNFIYQDATHVAGLITQAAFVEEARESGEDYPTV
AHTMIGMKRLNNLQHCVESALRDGVPGDVLETGVWRGGACIFARGILKAY
DVRDRTVWVADSFQGFPKITDDDHPMDAEMNLHQYNAAVDLPTSLATVQR
NFSRYGLLDDQVRFLPGWFKDTMPTAPFERLAVLRMDGDSYGATMDVLTH
AYPRLSPGGFAIIDDYCIPACREAVHEYRDRHGISDEIVEIDRQGVYWRR
SA
3D structure
PDB4x7v Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases.
ChainB
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.237: mycinamicin III 3''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B T55 M56 I57 E83 G85 V86 W87 D113 S114 G117 F118 L143 W170 F171 D189 T53 M54 I55 E81 G83 V84 W85 D111 S112 G115 F116 L141 W168 F169 D187
BS02 MIV B Y49 M56 L134 Y137 D189 D191 D217 I220 Q246 Y47 M54 L132 Y135 D187 D189 D215 I218 Q244
BS03 MG B D189 D216 D217 D187 D214 D215
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0036094 small molecule binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4x7v, PDBe:4x7v, PDBj:4x7v
PDBsum4x7v
PubMed25692963
UniProtQ49492|MYCF_MICGR Mycinamicin III 3''-O-methyltransferase (Gene Name=mycF)

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