Structure of PDB 4x24 Chain B

Receptor sequence
>4x24B (length=237) Species: 345073 (Vibrio cholerae O395) [Search protein sequence]
MKIGIIGAMQQEVAILKDLIEDVQEVNQAGCTFYSGQIQGVDVVLLQSGI
GKVSAALGTALLISQYAPDVVINTGSAGGFDASLNVGDVVISSEVRHHDA
DVTAFGYEIGQMPGQPAAFKADEKLMTVAEQALAQLPNTHAVRGLICTGD
AFICTAEGQQFIRQHFPSVVAVEMEASAIAQTCHQFKVPFVVVRAISDVA
DKESPLSFEEFLPLAAKSSSAMVLKMVELLKENLYFQ
3D structure
PDB4x24 Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.9: adenosylhomocysteine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TDI B M9 I50 S76 A77 G78 F152 I153 E173 M174 E175 D198 F208 M9 I50 S76 A77 G78 F152 I153 E173 M174 E175 D198 F208 MOAD: Ki=166pM
PDBbind-CN: -logKd/Ki=9.78,Ki=166pM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008782 adenosylhomocysteine nucleosidase activity
GO:0008930 methylthioadenosine nucleosidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0009086 methionine biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0019284 L-methionine salvage from S-adenosylmethionine
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4x24, PDBe:4x24, PDBj:4x24
PDBsum4x24
PubMed25806409
UniProtA5F5R2|MTNN_VIBC3 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (Gene Name=mtnN)

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