Structure of PDB 4x14 Chain B

Receptor sequence
>4x14B (length=258) Species: 10632 (JC polyomavirus) [Search protein sequence]
VEVLEVKTGVDSITEVECFLTPEMGDPDEHLRGFSKSISISDTFESDSPN
RDMLPCYSVARIPLPNLNILMWEAVTLKTEVIGVTSLMNVHSNGQATHDN
GAGKPVQGTSFHFFSVGGEALELQGVLFNYRTKYPDGTIFPKNATVQSQV
MNTEHKAYLDKNKAYPVECWVPDPTRNENTRYFGTLTGGENVPPVLHITN
TATTVLLDEFGVGPLCKGDNLYLSAVDVCGMFTNRSGSQQWRGLSRYFKV
QLRKRRVK
3D structure
PDB4x14 The Greater Affinity of JC Polyomavirus Capsid for alpha 2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL B S60 I61 S37 I38 PDBbind-CN: -logKd/Ki=2.92,Kd=1.2mM
BS02 SIA B L54 K59 S60 N264 S266 S268 Q270 L31 K36 S37 N234 S236 S238 Q240 PDBbind-CN: -logKd/Ki=2.92,Kd=1.2mM
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
Cellular Component
GO:0019028 viral capsid

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Molecular Function
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Cellular Component
External links
PDB RCSB:4x14, PDBe:4x14, PDBj:4x14
PDBsum4x14
PubMed25855729
UniProtP03089|VP1_POVJC Major capsid protein VP1

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