Structure of PDB 4x0f Chain B

Receptor sequence
>4x0fB (length=414) Species: 9606 (Homo sapiens) [Search protein sequence]
TPFAQVLASLRSVRNNFTIESYQKLAMETLEELDWALDQLETIQTYRSVS
EMASNKFKRMLNRELTHLSEMSRCGNQVSEYISNTFLDTENEDHLAKELE
DLNKWGLNIFNVAGYSHNRPLTAIMYAIFQERDLLKTFRISSDTFITYMM
TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA
AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHAD
IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGV
LLLDNYTDRIQVLRNMVHAADLSNPTKSLELYRQWTDRIMEEFFQQGDKE
RERGMEISPMADKHTACVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD
TLEDNRNWYQAMIP
3D structure
PDB4x0f Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4.
ChainB
Resolution3.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H410 H446 D447 D564 H167 H203 D204 D321
BS02 ROL B Y405 T579 I582 M583 F586 Q615 F618 Y162 T336 I339 M340 F343 Q372 F375 PDBbind-CN: -logKd/Ki=7.00,Kd=101nM
BS03 MG B H446 D447 T517 H203 D204 T274
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4x0f, PDBe:4x0f, PDBj:4x0f
PDBsum4x0f
PubMed25775568
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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