Structure of PDB 4wxh Chain B

Receptor sequence
>4wxhB (length=340) Species: 1950 (Streptomyces peucetius) [Search protein sequence]
QQIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTR
PEALLRLIRHLVAIGLLEEAPGEFVPTEVGELLADDHPAAQRAWHDLTQA
VARADISFTRLPDAIRTGRPTYESIYGKPFYEDLAGRPDLRASFDSLLAC
DQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMA
GTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILSFVLLNWPDHD
AVRILTRCAEALEPGGRILIHERDDLENSFNEQFSTELDLRMLVFLGGAL
RTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPA
3D structure
PDB4wxh Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L255 N256 E283 L312
Catalytic site (residue number reindexed from 1) L244 N245 E272 L300
Enzyme Commision number 2.1.1.292: carminomycin 4-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y142 R152 G186 E209 M210 G235 D236 F237 S251 F252 Y131 R141 G175 E198 M199 G224 D225 F226 S240 F241
BS02 3VL B F155 L159 F252 N256 E299 L300 R303 M304 F144 L148 F241 N245 E287 L288 R291 M292
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4wxh, PDBe:4wxh, PDBj:4wxh
PDBsum4wxh
PubMed26216966
UniProtQ06528|DNRK_STRPE Carminomycin 4-O-methyltransferase DnrK (Gene Name=dnrK)

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