Structure of PDB 4wvt Chain B

Receptor sequence
>4wvtB (length=79) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFA
CGGKLKNWEPGDRAWSEHRRHFPNCFFVL
3D structure
PDB4wvt The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
ChainB
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Q197 K206 L207 K208 W210 D214 E219 H223 Q45 K54 L55 K56 W58 D62 E67 H71
BS02 ZN B C200 C203 H220 C227 C48 C51 H68 C75
Gene Ontology
Molecular Function
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0043066 negative regulation of apoptotic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4wvt, PDBe:4wvt, PDBj:4wvt
PDBsum4wvt
PubMed25695766
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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