Structure of PDB 4wrt Chain B

Receptor sequence
>4wrtB (length=742) [Search protein sequence]
MNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYS
NKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEHP
GLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSF
RLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGFL
IKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRG
FVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISM
TVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIAR
LGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEG
TASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFV
NAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGF
VSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLF
IADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNL
RNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITKMDYD
AVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKP
VGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI
3D structure
PDB4wrt Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Q127 V133 C134 R135 N136 K185 N186 R203 K353 P371 N670 R671 S672 N675 Q127 V133 C134 R135 N136 K185 N186 R203 K353 P371 N663 R664 S665 N668
BS02 rna B H32 G33 T34 Y38 M356 K365 H32 G33 T34 Y38 M356 K365
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wrt, PDBe:4wrt, PDBj:4wrt
PDBsum4wrt
PubMed25409151
UniProtQ5V8Y6

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