Structure of PDB 4wo0 Chain B

Receptor sequence

>4wo0B (length=115) Species: 9606 (Homo sapiens)

CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTTAVVTN

3D structure

• PDB: 4wo0 Structural evidence for asymmetric ligand binding to transthyretin.
• Chain: B
• Resolution: 1.339 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AGI	B	K15 A108 L110 S117 T119	K6 A99 L101 S108 T110	BindingDB: IC50=653nM,Kd=250nM

Gene Ontology

Molecular Function

• GO:0005179 hormone activity
• GO:0005515 protein binding
• GO:0042802 identical protein binding
• GO:0070324 thyroid hormone binding

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0007165 signal transduction

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0035578 azurophil granule lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:4wo0, PDBe:4wo0, PDBj:4wo0
• PDBsum: 4wo0
• PubMed: 26249340
• UniProt: P02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)