Structure of PDB 4wef Chain B

Receptor sequence
>4wefB (length=431) Species: 11216 (Human respirovirus 3) [Search protein sequence]
ITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTVDGCI
RTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLNP
RISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASPGIEDIVLD
IVNYDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLE
HPINENVICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKGLNSI
PKLKVWTISMRQNYWGGEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITD
YSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIV
SSVILDSQKSRVNPVITYSTATERVNELAILNRTLSAGYTTTSCITHYNK
GYCFHIVEINHKSLNTLQPMLFKTEIPKSCS
3D structure
PDB4wef Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN)
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FSI B R192 E276 Y319 Y337 E409 R424 R502 Y530 R51 E135 Y178 Y196 E268 R283 R361 Y389
BS02 DF4 B R192 E276 Y319 E409 R424 R502 Y530 R51 E135 Y178 E268 R283 R361 Y389
BS03 SFJ B K358 Q365 A366 D471 G472 K217 Q224 A225 D330 G331
BS04 CA B D279 S282 P283 G284 A316 D138 S141 P142 G143 A175
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
Cellular Component
GO:0019031 viral envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wef, PDBe:4wef, PDBj:4wef
PDBsum4wef
PubMed26364554
UniProtQ6WJ03

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