Structure of PDB 4w6z Chain B

Receptor sequence
>4w6zB (length=347) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SIPETQKGVIFYESHGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAW
HGDWPLPVKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMAC
EYCELGNESNCPHADLSGYTHDGSFQQYATADAVQAAHIPQGTDLAQVAP
ILCAGITVYKALKSANLMAGHWVAISGAAGGLGSLAVQYAKAMGYRVLGI
DGGEGKEELFRSIGGEVFIDFTKEKDIVGAVLKATDGGAHGVINVSVSEA
AIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGSYVGNRAD
TREALDFFARGLVKSPIKVVGLSTLPEIYEKMEKGQIVGRYVVDTSK
3D structure
PDB4w6z Yeast alcohol dehydrogenase structure and catalysis.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C43 H44 T45 H48 H66 E67 C97 C100 C103 C111 D115 C153 R340
Catalytic site (residue number reindexed from 1) C43 H44 T45 H48 H66 E67 C97 C100 C103 C111 D115 C153 R340
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
1.1.1.54: allyl-alcohol dehydrogenase.
1.1.1.78: methylglyoxal reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C43 H66 E67 C153 C43 H66 E67 C153
BS02 ZN B C97 C100 C103 C111 C97 C100 C103 C111
BS03 ETF B T45 H66 C153 M270 V295 T45 H66 C153 M270 V295 MOAD: Ki=2.8mM
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0004552 octanol dehydrogenase (NAD+) activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019170 methylglyoxal reductase (NADH) activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0047655 allyl-alcohol dehydrogenase activity
GO:1904408 melatonin binding
GO:1990362 butanol dehydrogenase (NAD+) activity
Biological Process
GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway
GO:0006116 NADH oxidation
GO:0019655 glycolytic fermentation to ethanol
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4w6z, PDBe:4w6z, PDBj:4w6z
PDBsum4w6z
PubMed25157460
UniProtP00330|ADH1_YEAST Alcohol dehydrogenase 1 (Gene Name=ADH1)

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