Structure of PDB 4w1y Chain B

Receptor sequence
>4w1yB (length=433) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KHLPEPFRIRVIEPVKRTTRAYREEAIIKSGMNPFLLDSEDVFIDLLTDS
GTGAVTQSMQAAMMRGDEAYSGSRSYYALAESVKNIFGYQYTIPTHQGRG
AEQIYIPVLIKKREQEKGLDRSKMVAFSNYTVRNVYIKEAFDTGVRYDFK
GNFDLEGLERGIEEVGPNNVPYIVATITSNSAGGQPVSLANLKAMYSIAK
KYDIPVVMDSARFAENAYFIKQREAEYKDWTIEQITRETYKYADMLAMSA
KKDAMVPMGGLLCMKDDSFFDVYTECRTLCVVQEGLEGGAMERLAVGLYD
GMNLDWLAYRIAQVQYLVDGLEEIGVVCQQAGGHAAFVDAGKLLPHIPAD
QFPAQALACELYKVAGIRAVEIGSCPAELLRLTIPRATYTQTHMDFIIEA
FKHVKENAANIKGLTFTYEPKVLRHFTAKLKEV
3D structure
PDB4w1y Structures of Escherichia coli tryptophanase in holo and `semi-holo' forms.
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y74 D227 A229 K270 I396 H463
Catalytic site (residue number reindexed from 1) Y70 D209 A211 K252 I372 H425
Enzyme Commision number 4.1.99.1: tryptophanase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 B Q101 G102 R103 S267 Q97 G98 R99 S249
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0009034 tryptophanase activity
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0030955 potassium ion binding
GO:0042802 identical protein binding
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006568 tryptophan metabolic process
GO:0006569 tryptophan catabolic process
GO:0009072 aromatic amino acid metabolic process
GO:0042431 indole metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0060187 cell pole

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Molecular Function
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Cellular Component
External links
PDB RCSB:4w1y, PDBe:4w1y, PDBj:4w1y
PDBsum4w1y
PubMed25760702
UniProtP0A853|TNAA_ECOLI Tryptophanase (Gene Name=tnaA)

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