Structure of PDB 4uz6 Chain B

Receptor sequence
>4uz6B (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNREN
CDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSS
DVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGG
TGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITC
APTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVV
QWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPA
CLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDCPVHLVDSCPWPHCN
PSCPT
3D structure
PDB4uz6 Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GU4 B K224 V225 H419 K139 V140 H334
BS02 YYJ B R119 H419 R34 H334
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4uz6, PDBe:4uz6, PDBj:4uz6
PDBsum4uz6
PubMed25731175
UniProtQ6P988|NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (Gene Name=NOTUM)

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