Structure of PDB 4uxh Chain B

Receptor sequence
>4uxhB (length=164) Species: 5664 (Leishmania major) [Search protein sequence]
RGRIELIIGPMFAGKTTELMRRVKREIHARRSCFVIKYSKDLRAQAAVSQ
LTEVRDTWKRFDVLAIDEGQFFSDLVDFCNTAADAGKVVMVSALDGDYRR
KPFGQICELVPYCEAVDKLTAVCMMCHEQPACFTRRTVNVEQQELIGGAD
MYIATCRECYSKQQ
3D structure
PDB4uxh Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T5A B M13 F14 G16 K17 T18 M22 K39 D43 E85 Q87 F88 L111 D114 Y115 F120 T151 R153 Q160 L162 I163 G164 Y169 M11 F12 G14 K15 T16 M20 K37 D41 E68 Q70 F71 L94 D97 Y98 F103 T134 R136 Q143 L145 I146 G147 Y152 MOAD: ic50=1.1uM
BS02 ZN B C140 C143 C173 C176 C123 C126 C156 C159
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4uxh, PDBe:4uxh, PDBj:4uxh
PDBsum4uxh
PubMed25978379
UniProtQ4QC75

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