Structure of PDB 4ux9 Chain B

Receptor sequence
>4ux9B (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
NNFYSVEIGDSTFTVLKRYQNLKPIGSIVCAAYDAILERNVAIKKLSRPF
QNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELM
DANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS
DCTLKILDFGLARTAGPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGE
MVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYA
GYSFEKLFPDVLFPADSLKASQARDLLSKMLVIDASKRISVDEALQHPYI
NVWYDPSEAEAPPPKIPKELIYKEVMD
3D structure
PDB4ux9 Structure and Dynamics of the Mkk7-Jnk Signaling Complex.
ChainB
Resolution2.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D140 K142 N145 D158 T171
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Q117 M121 R127 S161 D162 C163 Q106 M110 R116 S150 D151 C152
BS02 ANP B I32 G33 S34 V40 A53 K55 M108 E109 M111 N114 K153 S155 N156 L168 D169 I25 G26 S27 V29 A42 K44 M97 E98 M100 N103 K142 S144 N145 L157 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ux9, PDBe:4ux9, PDBj:4ux9
PDBsum4ux9
PubMed25737554
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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