Structure of PDB 4uua Chain B

Receptor sequence
>4uuaB (length=266) Species: 7955 (Danio rerio) [Search protein sequence]
SSDLTAFREHFAKAKHIAIITGAGVSAESGVPTFRGPGGFWRKWQAQDLA
TPEAFSRDPSLVWEFYHYRREVMRSKMPNPAHLAIAECEARLGQQGRSVV
IITQNIDELHHRAGSKHVYEIHGSLFKTRCMSCGEVKANHKSPICPALDG
KGAPDPNTKEARIPVELLPRCERKSCNGLLRPHVVWFGETLDSDILTAVE
RELEKCDLCLVVGTSSIVYPAAMFAPQVASRGVPVAEFNMECTPATQRFK
YHFEGPCGSTLPPALE
3D structure
PDB4uua Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P64 T65 F66 R67 N137 D139 H154
Catalytic site (residue number reindexed from 1) P32 T33 F34 R35 N105 D107 H122
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C162 C165 C203 C208 C130 C133 C171 C176
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4uua, PDBe:4uua, PDBj:4uua
PDBsum4uua
PubMed25111069
UniProtQ6DHI5|SIR5_DANRE NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=sirt5)

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