Structure of PDB 4umn Chain B

Receptor sequence
>4umnB (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIATKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB4umn Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.
ChainB
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F55 Y56 Q59 F38 Y39 Q42
BS02 peptide B Q18 Q24 L54 F55 G58 I61 Y67 Q72 H73 V93 H96 Q1 Q7 L37 F38 G41 I44 Y50 Q55 H56 V76 H79
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4umn, PDBe:4umn, PDBj:4umn
PDBsum4umn
PubMed25115702
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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