Structure of PDB 4uee Chain B

Receptor sequence
>4ueeB (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
STDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKF
STGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDT
LDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFG
LSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLL
MYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASG
STIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIME
HTLNHP
3D structure
PDB4uee Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
ChainB
Resolution2.27 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H67 E70 R125 H194 E268
Enzyme Commision number 3.4.17.1: carboxypeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LA9 B H69 E72 R127 N144 R145 H196 S197 Y198 I243 Y248 S253 T268 E270 F279 H67 E70 R125 N142 R143 H194 S195 Y196 I241 Y246 S251 T266 E268 F277 BindingDB: Ki=0.140000nM
BS02 ZN B H69 E72 H196 H67 E70 H194
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4uee, PDBe:4uee, PDBj:4uee
PDBsum4uee
PubMed
UniProtP15085|CBPA1_HUMAN Carboxypeptidase A1 (Gene Name=CPA1)

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