Structure of PDB 4uci Chain B

Receptor sequence

>4uciB (length=370) Species: 162145 (human metapneumovirus)

VIDPTEQLAYFPKITFERLKNSNYAKGKLTRNYMILLPWQHVNRYNFVFS
STGCKVSLKTCIGKLMKDLNPKVLYFIGEGAGNWMARTACEYPDIKFVYR
SLKDDLDHHYPLEYQRVIGELSRIIDSGEGLSMETTDATQKTHWDLIHRV
SKDALLITLCDAEFKDRDDFFKMVILWRKHVLSCRICTTYGTDLYLFAKY
HAKDCNVKLPFFVRSVATFIMQGSKLSGSECYILLTLGHHNNLPCHGEIQ
NSKMKIAVCNDFYAAKKLDNKSIEANCKSLLSGLRIPINKKELNRQRRLL
TLSKWLTNKANTIIDWLEHILNSPKGELNYDFFEALENTYPNMIKLIDNL
GNAEIKKLIKVTGYMLVSKK

3D structure

• PDB: 4uci X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
• Chain: B
• Resolution: 2.21 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.375: NNS virus cap methyltransferase.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.88: GDP polyribonucleotidyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H1766 H1798 C1802 C1805	H148 H180 C184 C187
BS02	SAM	B	S1668 T1670 G1696 E1697 A1699 G1700 N1701 L1720 D1725 D1755 A1756 D1779 A1780 E1781 F1782	S50 T52 G78 E79 A81 G82 N83 L102 D107 D137 A138 D161 A162 E163 F164
BS03	GTP	B	Q1658 H1659 R1662 F1667 S1668 S1669 T1670 K1673 E1781 K1817 H1819 S1842 K1843 E1848 K1991	Q40 H41 R44 F49 S50 S51 T52 K55 E163 K199 H201 S224 K225 E230 K356
BS04	ADN	B	F1782 K1783 R1785 Y1818 H1819	F164 K165 R167 Y200 H201

External links

• PDB: RCSB:4uci, PDBe:4uci, PDBj:4uci
• PDBsum: 4uci
• PubMed: 26549102
• UniProt: Q91L20