Structure of PDB 4ubt Chain B

Receptor sequence
>4ubtB (length=392) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SMGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHA
GDVEQVIGGCVTQFGEQSNNISRVAWLTAGLPEHVGATTVDCQSGSGQQA
NHLIAGLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLP
NQFEAAERIAKRRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAP
VLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIHTAGTSSQIS
DGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVL
EKAGMKIGDIDIVEINEAFASVVLSWARVHEPDMDRVNVNGGAIALGHPV
GCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI
3D structure
PDB4ubt FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S93 H347 C377 G379
Catalytic site (residue number reindexed from 1) S94 H348 C378 G380
Enzyme Commision number 2.3.1.16: acetyl-CoA C-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B Q151 R221 T223 L231 A242 S246 I248 A317 F318 Q152 R222 T224 L232 A243 S247 I249 A318 F319
BS02 3G6 B Q92 S93 R136 Q151 A378 G379 Q93 S94 R137 Q152 A379 G380
Gene Ontology
Molecular Function
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0042802 identical protein binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process
GO:0010124 phenylacetate catabolic process
GO:0016042 lipid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4ubt, PDBe:4ubt, PDBj:4ubt
PDBsum4ubt
PubMed25482540
UniProtI6XHI4|FADA5_MYCTU Steroid 3-ketoacyl-CoA thiolase (Gene Name=fadA5)

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