Structure of PDB 4u97 Chain B

Receptor sequence
>4u97B (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKL
AALKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSC
LDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAK
ISDFVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVD
EHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLH
EKKNKRPDIKKVQQLLQEMT
3D structure
PDB4u97 IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
ChainB
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1) N135 K137 A139 N140 D153 T163
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU B M192 G193 E194 V200 A211 Y262 V263 Y264 M265 G268 A315 N316 L318 M27 G28 E29 V35 A46 Y86 V87 Y88 M89 G92 A139 N140 L142
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4u97, PDBe:4u97, PDBj:4u97
PDBsum4u97
PubMed25201411
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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