Structure of PDB 4u8d Chain B

Receptor sequence
>4u8dB (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
FPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCR
LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQ
KALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRR
DTAQQGVVNFPYDDFIQCVMSV
3D structure
PDB4u8d INVESTIGATING THE CONFORMATIONAL CHANGES of SORCIN TO SHED LIGHT ON SIGNAL TRANSDUCTION IN THE APOPTOTIC PROCESS
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F95 G118 V120
Catalytic site (residue number reindexed from 1) F69 G92 V94
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D83 D85 S87 T89 D57 D59 S61 T63
BS02 MG B T31 Q32 T5 Q6
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0005102 signaling receptor binding
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0001508 action potential
GO:0006816 calcium ion transport
GO:0006880 intracellular sequestering of iron ion
GO:0006942 regulation of striated muscle contraction
GO:0007165 signal transduction
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0008016 regulation of heart contraction
GO:0010459 negative regulation of heart rate
GO:0010649 regulation of cell communication by electrical coupling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051924 regulation of calcium ion transport
GO:0055118 negative regulation of cardiac muscle contraction
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 regulation of cardiac muscle cell contraction
GO:1901077 regulation of relaxation of muscle
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031982 vesicle
GO:0033017 sarcoplasmic reticulum membrane
GO:0042584 chromaffin granule membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4u8d, PDBe:4u8d, PDBj:4u8d
PDBsum4u8d
PubMed
UniProtP30626|SORCN_HUMAN Sorcin (Gene Name=SRI)

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