Structure of PDB 4u4s Chain B

Receptor sequence
>4u4sB (length=263) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKL
KNKWWYDKGECGS
3D structure
PDB4u4s Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3C1 B P494 F495 M496 L751 P105 F106 M107 L239 MOAD: Kd=1200uM
PDBbind-CN: -logKd/Ki=2.92,Kd=1200uM
BS02 3C1 B P494 S729 K730 G731 P105 S217 K218 G219 MOAD: Kd=1200uM
PDBbind-CN: -logKd/Ki=2.92,Kd=1200uM
BS03 GLU B Y450 L479 T480 R485 G653 S654 T655 E705 Y61 L90 T91 R96 G141 S142 T143 E193
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4u4s, PDBe:4u4s, PDBj:4u4s
PDBsum4u4s
PubMed25375781
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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