Structure of PDB 4u42 Chain B

Receptor sequence
>4u42B (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTKYSHHRN
IATYYGAFIKKSPPDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYIS
REILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVNTFIGTPYWM
APEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLI
PRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNE
RQVRIQLKDHIDRTR
3D structure
PDB4u42 Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
ChainB
Resolution2.504 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D153 K155 Q157 N158 D171 T191
Catalytic site (residue number reindexed from 1) D119 K121 Q123 N124 D137 T146
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3C8 B Y36 A52 K54 M105 E106 F107 C108 L160 V170 D171 Y20 A36 K38 M71 E72 F73 C74 L126 V136 D137 BindingDB: IC50=6.20nM,Ki=10.7nM
BS02 MG B S77 H78 H79 I82 T84 S46 H47 H48 I51 T53
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4u42, PDBe:4u42, PDBj:4u42
PDBsum4u42
PubMed
UniProtO95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (Gene Name=MAP4K4)

[Back to BioLiP]