Structure of PDB 4u3j Chain B

Receptor sequence
>4u3jB (length=417) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MREIIHISTGQCGNQIGAAFWETICGEHGLDFNGTYHGHDDIQKERLNVY
FNEASSGKWVPRSINVDLEPGTIDAVRNSAIGNLFRPDNYIFGQSSAGNV
WAKGHYTEGAELVDSVMDVIRREAEGCDSLQGFQITHSLGGGTGSGMGTL
LISKIREEFPDRMMATFSVLPSPKTRVEPYNATLSVHQLVEHSDETFCID
NEALYDICQLKQPSYGDLNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNL
VPFPRLHFFMVGYAPLTARSLTVPELTQQMFDAKNMMAAADPRNGRYLTV
AAFFRGKVSVKEVEDEMHKVQSKNSDYFVEWIPNNVQTAVCSVAPQGLDM
AATFIANSTSIQELFKRVGDQFSAMFKRKAFLHWYTSEGMDELEFSEAES
NMNDLVSEYQQYQEATV
3D structure
PDB4u3j A tethered delivery mechanism explains the catalytic action of a microtubule polymerase.
ChainB
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B G10 Q11 C12 A97 N99 S138 G141 G142 T143 E181 N204 Y222 N226 G10 Q11 C12 A97 N99 S138 G141 G142 T143 E178 N201 Y215 N219
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000022 mitotic spindle elongation
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process
GO:0031122 cytoplasmic microtubule organization
GO:0046677 response to antibiotic
GO:0090307 mitotic spindle assembly
GO:0090316 positive regulation of intracellular protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0045298 tubulin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4u3j, PDBe:4u3j, PDBj:4u3j
PDBsum4u3j
PubMed25097237
UniProtP02557|TBB_YEAST Tubulin beta chain (Gene Name=TUB2)

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