Structure of PDB 4u21 Chain B

Receptor sequence
>4u21B (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKN
KWWYDKGECG
3D structure
PDB4u21 Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
ChainB
Resolution1.3908 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FWD B Y61 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 Y59 L88 T89 R94 L136 G139 S140 T141 L190 E191 M194 BindingDB: Ki=4nM,EC50=460nM
BS02 FWF B I92 K104 P105 K218 I90 K102 P103 K216
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4u21, PDBe:4u21, PDBj:4u21
PDBsum4u21
PubMed25109876
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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