Structure of PDB 4u0o Chain B

Receptor sequence
>4u0oB (length=273) Species: 197221 (Thermosynechococcus vestitus BP-1) [Search protein sequence]
PSWLRISTVQRLVRQYGIHTICEEGRCPNRGECYGQKTATFLLLGPTCTR
ACAFCQVEKGHAPAAVDPEEPTKIAAAVATLGLRYVVLTSVARDDLPDQG
AGQFVATMAAIRQRCPGTEIEVLSPDFRMDRGRLSQRDCIAQIVAAQPAC
YNHNLETVRRLQGPVRRGATYESSLRVLATVKELNPDIPTKSGLMLGLGE
TEAEIIETLKDLRRVGCDRLTLGQYLPPSLSHLPVVKYWTPEEFNTLGNI
ARELGFSHVRSGPLVRSSYHAAE
3D structure
PDB4u0o Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.8: lipoyl synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 B C63 C67 C70 C48 C52 C55
BS02 SF4 B C37 C42 N44 C48 T55 S283 Y284 C22 C27 N29 C33 T40 S268 Y269
BS03 MTA B F69 E171 M210 L241 R281 S283 F54 E156 M195 L226 R266 S268
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016992 lipoate synthase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009107 lipoate biosynthetic process
GO:0009249 protein lipoylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4u0o, PDBe:4u0o, PDBj:4u0o
PDBsum4u0o
PubMed25100160
UniProtQ8DLC2|LIPA2_THEVB Lipoyl synthase 2 (Gene Name=lipA2)

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