Structure of PDB 4txz Chain B

Receptor sequence
>4txzB (length=366) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961) [Search protein sequence]
TWNFHQYYTNRNDGLMGKLVLTDEEKNNLKALRKIIRLRTRDVFEEAKGI
AKAVKKSALTFEIIQEKVSTTQIKHLSDSEQREVAKLIYEMDDDARDEFL
GLTPRFWTQGSFQYDTLNRPFQPGQEMDIDDGTYMPMPIGHSLLILLVDA
SLKSLVAENHGWKFEAKQTCGRIKIEAEKTHIDVPMYAIPKDEFDSENVN
LALREGDRKWINSDPKIVEDWFNDSCIRIGKHLRKVCRFMKAWRDAQWDV
GGPSSISLMAATVNILDSVAHDASDLGETMKIIAKHLPSEFARGVESPDS
TDEKPLFPPSYKHGPREMDIMSKLERLPEILSSAESADSKSEALKKINMA
FGNRVTNSELIVLAKA
3D structure
PDB4txz Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D132 D134 D194 D128 D130 D183
BS02 MG B D132 D134 D128 D130
BS03 G2P B Q113 G114 S115 Y118 D132 D134 P262 K288 S302 D349 L353 Q109 G110 S111 Y114 D128 D130 P215 K241 S255 D302 L306
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0052621 diguanylate cyclase activity
GO:0140701 3',3'-cyclic GMP-AMP synthase activity
Biological Process
GO:0009117 nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0050922 negative regulation of chemotaxis
GO:0051607 defense response to virus
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4txz, PDBe:4txz, PDBj:4txz
PDBsum4txz
PubMed25131990
UniProtQ9KVG7|DNCV_VIBCH Cyclic GMP-AMP synthase (Gene Name=dncV)

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