Structure of PDB 4twt Chain B

Receptor sequence
>4twtB (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
DKPVAHVVANPQAEGQLQWLNRLLANGVELRDNQLVVPSEGLYLIYSQVL
FKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETAKPWYEPI
YLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
3D structure
PDB4twt Subunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide.
ChainB
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B L57 Y59 L120 G148 Q149 L44 Y46 L102 G130 Q131
BS02 38A B H15 Y59 H6 Y46
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4twt, PDBe:4twt, PDBj:4twt
PDBsum4twt
PubMed25614525
UniProtP01375|TNFA_HUMAN Tumor necrosis factor (Gene Name=TNF)

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