Structure of PDB 4tug Chain B

Receptor sequence
>4tugB (length=306) Species: 243232 (Methanocaldococcus jannaschii DSM 2661) [Search protein sequence]
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDL
FNDLRPPVKALRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLALL
KDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNY
KKKILMLHQGINPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGIL
AYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIEKIDIECREFV
EVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKA
IIVDDE
3D structure
PDB4tug DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.
ChainB
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R14 N17 R14 N17
BS02 dna B N17 L18 D19 K129 N17 L18 D19 K129
BS03 MG B D49 N84 H158 H186 D49 N84 H158 H186
BS04 MG B D8 H10 D49 H188 D8 H10 D49 H188
Gene Ontology
Molecular Function
GO:0000403 Y-form DNA binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0045027 DNA end binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006302 double-strand break repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4tug, PDBe:4tug, PDBj:4tug
PDBsum4tug
PubMed25107472
UniProtQ58719|MRE11_METJA DNA double-strand break repair protein Mre11 (Gene Name=mre11)

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