Structure of PDB 4tu9 Chain B

Receptor sequence
>4tu9B (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLGSARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQIN
QDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGAHKLF
IGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINV
TDQAIAGLNGMQLGDKKLLVQRAS
3D structure
PDB4tu9 Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
ChainB
Resolution1.992 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B F262 G264 G265 V291 S294 K300 Y302 F304 K328 K329 L331 Q333 A335 F100 G102 G103 V129 S132 K138 Y140 F142 K166 K167 L169 Q171 A173
BS02 rna B Y152 K195 F197 F199 K225 R227 P229 H230 Y10 K53 F55 F57 K83 R85 P87 H88
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:4tu9, PDBe:4tu9, PDBj:4tu9
PDBsum4tu9
PubMed25422459
UniProtP26368|U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (Gene Name=U2AF2)

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