Structure of PDB 4to5 Chain B

Receptor sequence

>4to5B (length=480) Species: 9606 (Homo sapiens) [Search protein sequence]

TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYF
VQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4to5 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	TTP	B	N119 H125	N6 H12
BS02	TTP	B	V156 F157 R372 H376 K377	V43 F44 R253 H257 K258
BS03	GTP	B	K116 V117 I118 D137 R145	K3 V4 I5 D24 R32
BS04	TTP	B	R333 R352 K354 K523	R214 R233 K235 K404
BS05	DCP	B	Q149 L150 R164 R206 H210 H215 Y315 D319 Y374	Q36 L37 R51 R93 H97 H102 Y196 D200 Y255
BS06	GTP	B	Y155 V156 V378 R451 K455	Y42 V43 V259 R332 K336

External links

PDB	RCSB:4to5, PDBe:4to5, PDBj:4to5
PDBsum	4to5
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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