Structure of PDB 4to0 Chain B

Receptor sequence

>4to0B (length=480) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYF
VQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4to0 Structural basis of cellular dNTP regulation by SAMHD1.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DCP	B	L150 R164 R206 H210 H215 H233 D311 Y315 D319 R366 Y374	L38 R52 R94 H98 H103 H121 D192 Y196 D200 R247 Y255
BS02	DTP	B	V156 F157 R372 H376 K377	V44 F45 R253 H257 K258
BS03	GTP	B	Y155 V156 V378 R451	Y43 V44 V259 R332
BS04	GTP	B	K116 V117 I118 D137 R145	K4 V5 I6 D25 R33
BS05	DTP	B	R333 R352 K354 N358 K523	R214 R233 K235 N239 K404

External links

PDB	RCSB:4to0, PDBe:4to0, PDBj:4to0
PDBsum	4to0
PubMed	25267621
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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