Structure of PDB 4tnx Chain B

Receptor sequence
>4tnxB (length=479) Species: 9606 (Homo sapiens) [Search protein sequence]
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD
CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL
HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY
TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK
REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYF
VQWCADRNFTKPQDGDVIAPLITPQKKEW
3D structure
PDB4tnx Structural basis of cellular dNTP regulation by SAMHD1.
ChainB
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B Y155 V156 V378 R451 K455 Y42 V43 V259 R332 K336
BS02 DGT B R333 R352 K354 N358 K523 R214 R233 K235 N239 K404
BS03 DGT B V117 N119 V4 N6
BS04 GTP B K116 V117 I118 D137 Q142 R145 K3 V4 I5 D24 Q29 R32
BS05 DGT B V156 F157 I325 R372 H376 K377 V43 F44 I206 R253 H257 K258
External links
PDB RCSB:4tnx, PDBe:4tnx, PDBj:4tnx
PDBsum4tnx
PubMed25267621
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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