Structure of PDB 4tmw Chain B

Receptor sequence
>4tmwB (length=345) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence]
GHMNKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGAT
YFPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCN
IAILVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNG
FRESFALQNKAVQNEFRNRLDQVKLQFAEQGFNSELFYENKNFARYVSLV
PTSAHTGEGIPDMLKLIVQLCQERMASSLMYLSELQATVLEVKAIEGFGV
TIDVILSNGILREGDRIVLCGLEGPIKTNIRALLTPAPMRELRIKGQYIH
HKEVKAAQGVKISAPGLEGAIAGSRLLVVGPDDDEEELEEEVESD
3D structure
PDB4tmw A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
ChainB
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B V532 D533 T534 G535 K536 T537 K538 Q549 I556 T557 G597 N648 K649 D651 R652 S716 A717 H718 V19 D20 T21 G22 K23 T24 K25 Q36 I43 T44 G84 N135 K136 D138 R139 S203 A204 H205 MOAD: Kd=4.1uM
BS02 MG B T537 T557 T24 T44
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4tmw, PDBe:4tmw, PDBj:4tmw
PDBsum4tmw
PubMed25225612
UniProtG0S8G9|IF2P_CHATD Eukaryotic translation initiation factor 5B (Gene Name=CTHT_0029840)

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