Structure of PDB 4tkf Chain B

Receptor sequence
>4tkfB (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
FQGSPDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLW
ERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFG
AGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKS
FLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQ
IMRP
3D structure
PDB4tkf Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1081 H1084 C1089 C1092 C125 H128 C133 C136
BS02 33C B H1031 S1033 F1035 A1038 I1039 G1043 F1044 D1045 H1048 Y1060 Y1071 I1075 H75 S77 F79 A82 I83 G87 F88 D89 H92 Y104 Y115 I119 BindingDB: IC50=31nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tkf, PDBe:4tkf, PDBj:4tkf
PDBsum4tkf
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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