Structure of PDB 4tk0 Chain B

Receptor sequence
>4tk0B (length=205) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFQGDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKL
WERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMF
GAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGK
SFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITY
QIMRP
3D structure
PDB4tk0 Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1081 H1084 C1089 C1092 C126 H129 C134 C137
BS02 32Z B H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H76 G77 Y105 F106 A107 K112 S113 Y116 E183
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tk0, PDBe:4tk0, PDBj:4tk0
PDBsum4tk0
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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