Structure of PDB 4tjw Chain B

Receptor sequence
>4tjwB (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCN
KKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIG
GMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVT
LGKSFLQFSAMKMAHSPPGHHSVTGRPSVGLALAEYVIYRGEQAYPEYLI
TYQIMRP
3D structure
PDB4tjw Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1081 H1084 C1089 C1092 C129 H132 C137 C140
BS02 P34 B H1031 G1032 Y1050 G1052 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 E1138 H79 G80 Y98 G100 Y108 F109 A110 K115 S116 Y119 I123 E185 BindingDB: IC50=2951nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4tjw, PDBe:4tjw, PDBj:4tjw
PDBsum4tjw
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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