Structure of PDB 4s15 Chain B

Receptor sequence
>4s15B (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
SMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREV
MWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRM
CRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTED
EIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILT
KLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPA
3D structure
PDB4s15 Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells.
ChainB
Resolution1.897 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K339 Q349 Q352 E509 K71 Q81 Q84 E241
BS02 4D8 B Q289 Y290 W320 M368 Y380 L394 Q21 Y22 W52 M100 Y112 L126
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4s15, PDBe:4s15, PDBj:4s15
PDBsum4s15
PubMed25651181
UniProtP35398|RORA_HUMAN Nuclear receptor ROR-alpha (Gene Name=RORA)

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